HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromophenol → 1-(diphenylmethyl)-3-hydroxy-3-(5-hydroxy-2,1,3-benzoxadiazol-4-yl)-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromophenol | HCID 11563 | — |
| Reactant | 1-(diphenylmethyl)-1H-indole-2,3-dione | HCID 1969277 | — |
| Reactant | 1-((5-(Trifluoromethyl)furan-2-yl)methyl)indoline-2,3-dione | HCID 67356488 | — |
| Reactant | 5-Hydroxybenzofurazan | HCID 135456836 | — |
| Product | 1-(diphenylmethyl)-3-hydroxy-3-(5-hydroxy-2,1,3-benzoxadiazol-4-yl)-1,3-dihydro-2H-indol-2-one | HCID 136348347 | — |
Reaction Steps
Following the procedure as described in PREPARATION 2A and making non-critical variations using 2,1,3-benzoxadiazol-5-ol to replace 3-bromophenol, and 1-(diphenylmethyl)-1H-indole-2,3-dione to replace 1-((5-(trifluoromethyl)furan-2-yl)methyl)indoline-2,3-dione, 1-(diphenylmethyl)-3-hydroxy-3-(5-hydroxy-2,1,3-benzoxadiazol-4-yl)-1,3-dihydro-2H-indol-2-one was obtained (71%) as a colorless solid: MS (ES+) m/z 472.0 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263606B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-41d566c7e7b744478a81b1e08c70e6a0 |
| Source note | uspto-grants-2012_09 |