反应详情

1-Acetyl-3,3-dimethyl-6-nitroindoline (250 mg) was dissolved in MeOH (20 mL), the mixture was bubbled with H2 for 10 min. 10% Pd/C (50 mg) was added and the mixture was stirred under H2 overnight. The mixture was filtered through Celite® and concentrated in vacuo. The crude material was purified by flash chromatography on silica gel with 1:1 EtOAc:CH2Cl2 to afford the title compound as a white crystalline material. MS: 205 (M+1). Calc'd. for C12H16N2O—204.27.

1. customthe mixture was bubbled with H2 for 10 min
2. addition10% Pd/C (50 mg) was added
3. filtrationThe mixture was filtered through Celite®
4. concentrationconcentrated in vacuo
5. customThe crude material was purified by flash chromatography on silica gel with 1:1 EtOAc