Trifluoroacetic acid methylene chloride → {3-[2-(2-Isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-azetidin-1-yl}-acetic acid TFA salt

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Following a similar procedure to 8-azetidin-3-yl-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene TFA salt 235 using {3-[2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-azetidin-1-yl}-acetic acid tent-butyl ester and TFA:DCM (1:2), {3-[2-(2-Isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-azetidin-1-yl}-acetic acid TFA salt was isolated as a white solid (75 mg, 90%). 1H NMR δ (ppm) (DMSO-d6): 8.35 (1 H, d, J=8.20 Hz), 8.11 (1 H, d, J=0.75 Hz), 7.29 (1 H, d, J=8.33 Hz), 7.21 (1 H, s), 5.85-5.77 (1 H, m), 4.48-4.39 (2 H, m), 4.41-4.35 (2 H, m), 4.36-4.22 (3 H, m), 3.48-3.42 (2H, m), 1.55 (6 H, d, J=6.59 Hz) plus 2 protons obscured by the water peak and 2 exchangeable protons not observed.

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