Methylamine hydrochloride → 2-(3-amino-1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Methylamine hydrochloride	HCID 6364545	—
Reactant	2-[5-Amino-2-(2,4-difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-8-carboxylic acid	HCID 67050538	—
Product	2-(3-amino-1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxamide	HCID 51001985	—

Reaction Steps

Similarly to as described in General Procedure D, 2-[5-Amino-2-(2,4-difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-8-carboxylic acid was reacted with methylamine hydrochloride to give 127 as a colorless solid after reverse phase HPLC (140 mg). LCMS: 454.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08263633B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-f191e7f2c9e540ecb4ae6fca7bc88c3b
Source note	uspto-grants-2012_09