2-(Isopropylamino)ethanol → HCID 51355043, compound

HRID 2385745Notes

Reaction equation

HRID 2385745 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([OH:20])=O)[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH:23]([NH:26][CH2:27][CH2:28][OH:29])([CH3:25])[CH3:24]>>[OH:29][CH2:28][CH2:27][N:26]([CH:23]([CH3:25])[CH3:24])[C:18]([C:12]1[S:13][C:14]2[CH2:15][CH2:16][O:17][C:8]3[CH:7]=[C:6]([C:4]4[CH:3]=[N:2][NH:1][CH:5]=4)[CH:22]=[CH:21][C:9]=3[C:10]=2[N:11]=1)=[O:20]

Participants

3

Reactant 2

HCID 79942-(Isopropylamino)ethanolHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 51355043HCID 51355043, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with 2-(isopropylamino)ethanol (1.2 equiv) to give 209 (10.8 mg, M+1 399.1)

Sources & evidence

ORD record
ord-7f0ee71dcd9a478c987bc827e954cf3d
Source dataset
uspto-grants-2012_09
Patent number
US08263633B2

Reaction notes

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