HCID 42258008, compound → HCID 58203716, compound

HRID 2385755Notes

Reaction equation

HRID 2385755 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([OH:20])=O)[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH:23]([N:26]1[CH2:30][CH2:29][C@@H:28]([CH2:31][NH:32][CH3:33])[CH2:27]1)([CH3:25])[CH3:24]>>[CH:23]([N:26]1[CH2:30][CH2:29][C@H:28]([CH2:31][N:32]([CH3:33])[C:18]([C:12]2[S:13][C:14]3[CH2:15][CH2:16][O:17][C:8]4[CH:7]=[C:6]([C:4]5[CH:3]=[N:2][NH:1][CH:5]=5)[CH:22]=[CH:21][C:9]=4[C:10]=3[N:11]=2)=[O:20])[CH2:27]1)([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 42258008HCID 42258008, compoundHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58203716HCID 58203716, compound

Procedure

Following Example 216, to a well stirred solution of 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid and (S)-1-(1-isopropylpyrrolidin-3-yl)-N-methylmethanamine to give 222. MS: (ESI+)=452.2

Sources & evidence

ORD record
ord-6368245217c24cfabf065f0ff8e497c2
Source dataset
uspto-grants-2012_09
Patent number
US08263633B2

Reaction notes

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