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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2385921Generated: October 30, 2026

Hydrochloric Acid → HCID 58204138, compound

https://huagongshe.com/reaction/2385921

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTetrahydropyranyl etherHCID 263182—
Reactant1-[2-(oxan-2-yloxy)ethyl]-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 59341819—
ReactantHCID 67050596HCID 67050596—
ProductHCID 58204138HCID 58204138—

Reaction Steps

Similar to as described in General Procedure C, 5-(8-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-ylamine was reacted with 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Subsequent to the Suzuki coupling, deprotection of the tetrahydropyranyl ether was accomplished by adding 2N HCl to the crude reaction mixture. Purification by reverse phase HPLC gave 403 as a colorless solid (16 mg). LCMS: 438.1

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08263633B2
Source datasetuspto-grants-2012_09
ORD IDord-5f6db6e461a645d89bcaefd45907fc57
Source noteuspto-grants-2012_09