HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → HCID 58204120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 7-Fluoro-3,4-dihydro-1-benzoxepin-5(2H)-one | HCID 12243564 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 58204120 | HCID 58204120 | — |
Reaction Steps
Dissolved 7-fluoro-3,4-dihydrobenzo[b]oxepin-5(2H)-one (1.58 g, 8.77 mmol) in 80 mL ether and added bromine (0.497 mL, 9.65 mmol) and allowed the reaction mixture to stir at room temperature 20 hours. Reaction was complete by LCMS. Concentrated the reaction in vacuo and purified by flash hromatography (0 to 30% ethyl acetate/heptanes). Concentrated in vacuo and NMR indicated 4-bromo-7-fluoro-3,4-dihydrobenzo[b]oxepin-5(2H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263633B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-d81269d466d945cfa0499026aec191fe |
| Source note | uspto-grants-2012_09 |