1-Fluoro-4-(methylsulphonyl)benzene → [4-(4-Methanesulfonyl-phenoxy)-naphthalen-2-yl]-acetic acid

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Reaction Steps

Starting with (4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester (108 mg, 0.5 mmol) and 1-fluoro-4-methanesulfonyl-benzene (174 mg, 1.0 mmol), using a method analogous to the one described for example 1-1, the final two steps), 4-(4-methanesulfonyl-phenoxy)-naphthalen-2-yl]-acetic acid (65.8 mg, 37%) was obtained as a white solid. 1H NMR (400 MHz, CD3OD) δ ppm 7.89-7.94 (m, 4H), 7.71 (s, 1H), 7.54 (dt, J=8.08, 4.04 Hz, 1H), 7.48 (s, 2H), 7.14-7.19 (m, 3H), 3.80 (s, 2H), 3.11 (s, 3H); MS cald. for C19H16O5S 356, obsd. (ESI+) [(M+H)+] 357.

Provenance & Evidence