HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Fluoro-4-(methylsulphonyl)benzene → [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Fluoro-4-(methylsulphonyl)benzene | HCID 67994 | — |
| Reactant | (6-Chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester | HCID 59326538 | — |
| Reactant | 2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester | HCID 67303799 | — |
| Product | [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326613 | 33.4% |
Reaction Steps
Starting with (6-chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (132 mg, 0.5 mmol) and 1-fluoro-4-methanesulfonyl-benzene (174 mg, 1.0 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [6-chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (70 mg, 33%) was obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642629B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-a59767866add42b69dd7390a8d6045d1 |
| Source note | uspto-grants-2014_02 |