HCID 44407298, compound → HCID 67153148, compound

HRID 2386169Notes

Reaction equation

HRID 2386169 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17]/[CH:18]=[C:19](\[CH3:32])/[CH2:20][N:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:24][CH2:23][C:22]3=[O:31])[CH2:13][CH2:12]2)[CH:8]=[C:7]([C:33]([F:36])([F:35])[F:34])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH:19]([CH3:32])[CH2:20][N:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:24][CH2:23][C:22]3=[O:31])[CH2:15][CH2:16]2)[CH:8]=[C:7]([C:33]([F:35])([F:36])[F:34])[N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 44407298HCID 44407298, compound

Product 1

HCID 67153148HCID 67153148, compoundYield 27.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Pd/C (10%, 10.0 mg) was added to a solution of 1-((2E)-4-{4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}-2-methylbut-2-enyl)-3,4-dihydroquinolin-2(1H)-one (0.08 mmol, 49.99 mg) from example 12 in methanol (10 ml), and hydrogenation was then carried out at room temperature for 12 hours. 11.10 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-3f37dc5205a8431aafdae0f5da52cd71
Source dataset
uspto-grants-2012_09
Patent number
US08268815B2

Reaction notes

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