HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Acetamido-4-methylthiazole | HCID 280907 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide | HCID 822437 | — |
Reaction Steps
To N-(4-methylthiazol-2-yl)acetamide (39.48 g) in acetic acid (200 ml) under a water-ice bath was added dropwise bromine (16 ml). After 2 h, water (500 ml) was added. Filtration, washing with water (3×) and drying gave N-(5-bromo-4-methylthiazol-2-yl) acetamide as off-white solid (52.13 g). H1-NMR (300 MHz, d6-DMSO) 12.27 (s, 1 H), 2.22 (s, 3 H), 2.13 (s, 3 H) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268818B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-0d0e5602462f4e4ca9815af450f3ed94 |
| Source note | uspto-grants-2012_09 |