(1-Bromo-3,6-difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester → (3,6-Difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester

Participants

Reaction Steps

To a solution of (1-bromo-3,6-difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester (50 mg, 0.152 mmol) in methanol was added 10% palladium on carbon (10 mg). After being stirred at room temperature under a hydrogen atmosphere overnight, the resulting mixture was filtered. The filtrate was concentrated in vacuo to afford (3,6-difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester (25 mg, 65%) as a white solid.

Provenance & Evidence