反应详情

3-Chloro-2-fluorobenzoic acid (10.0 g, 0.06 mol), thionyl chloride (31 ml, 50 g, 0.4 mol) and dry toluene (40 ml) were heated at reflux for 3 h. The solution was cooled and the volatiles were removed in vacuo. The residue was azeotroped with toluene (2×30 ml) to give the product (11.5 g) as a clear yellow oil.

1. temperatureat reflux for 3 h
2. temperatureThe solution was cooled
3. customthe volatiles were removed in vacuo
4. customThe residue was azeotroped with toluene (2×30 ml)