関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Morpholinecarboxylic acid | HCID 3340152 | — |
| 反応物 | 2,4,6-Trichloropyrimidin-5-amine | HCID 13392155 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 86651565 | HCID 86651565 | 36.7% |
反応手順
A round-bottom flask was charged with 2,4,6-trichloropyrimidin-5-amine (982 mg, 4.95 mmol), morpholine-3-carboxylic acid (649 mg, 4.95 mmol) and triethylamine (2.78 mL, 19.79 mmol) in ethanol (20 mL). The mixture was heated at 75° C. for 3 days then diluted with water and extracted with EtOAc. The organic layer was dried over magnesium sulfate, filtered and dried in vacuo to give 500 mg of crude 2,4-dichloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one which was used without further purification. MS [M+H] Found 275.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08268819B2 |
|---|
| 出典データセット | uspto-grants-2012_09 |
|---|
| ORD ID | ord-8a57b2a5a36a4a06b040829aaa0f809e |
|---|
| 出典メモ | uspto-grants-2012_09 |
|---|
