HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-(ethylsulfonyl)pyridine → [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-1-methyl-naphthalen-2-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-(ethylsulfonyl)pyridine | HCID 53393184 | — |
| Reactant | (6-Fluoro-4-hydroxy-1-methyl-naphthalen-2-yl)acetic acid methyl ester | HCID 59326584 | — |
| Reactant | 2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester | HCID 67303799 | — |
| Product | [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-1-methyl-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326521 | 75% |
Reaction Steps
Starting with (6-fluoro-4-hydroxy-1-methyl-naphthalen-2-yl)acetic acid methyl ester (18 mg, 0.073 mmol) and 2-bromo-5-ethanesulfonyl-pyridine (27 mg, 0.109 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [4-(5-ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-1-methyl-naphthalen-2-yl]-acetic acid methyl ester (22.7 mg, 75%) was obtained as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642629B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-c465bafad2a345ea88c1e1c36d5c4835 |
| Source note | uspto-grants-2014_02 |