HCID 67304733, compound → HCID 59326610, compound

Participants

Reaction Steps

To a solution of 3-[4-(4-ethanesulfonyl-phenoxy)-6-fluoro-3-methyl-naphthalen-2-yl]-acrylic acid ethyl ester (40 mg, 0.09 mmol) in ethyl acetate (3 mL) was added 10% palladium on carbon (4 mg). The resulting mixture was stirred vigorously under a hydrogen (balloon) atmosphere overnight, and then filtered. The filtrate was concentrated in vacuo to give 3-[4-(4-ethanesulfonyl-phenoxy)-6-fluoro-3-methyl-naphthalen-2-yl]-propionic acid ethyl ester (30 mg, 75%) as a yellow solid, which was used for the next step without any further purification.

Provenance & Evidence