Ethylamine → [3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amine

HRID 2386374Notes

Reaction equation

HRID 2386374 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[CH2:16]([NH2:18])[CH3:17]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH2:11][NH:18][CH2:16][CH3:17])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 6341EthylamineHCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

Product 1

HCID 86603259[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amine

Procedure

Intermediate 1 was coupled with ethylamine following procedure B. LC-MS showed the product had the expected M+H+ of 248.

Sources & evidence

ORD record
ord-c50bc5e3239e42088136f81497076236
Source dataset
uspto-grants-2012_09
Patent number
US08268822B2

Reaction notes

Loading…