HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoformate → 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Product | 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine | HCID 86603261 | — |
Reaction Steps
Intermediate 1 (3.69 g) was refluxed for two hours in trimethylorthoformate containing 10 mL of 4N HCl/dioxane. The solvent was removed by rotary evaporation to give product, which showed the expected M+H+ of 265 by LC-MS.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-84ca9525207540389837a37219b4733d |
| Source note | uspto-grants-2012_09 |