HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tyramine → 4-{2-[4-(4-Ethoxy-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tyramine | HCID 5610 | — |
| Reactant | 4-(4-Ethoxy-phenyl)-2-chloro-pyrimidine | HCID 24901979 | — |
| Product | 4-{2-[4-(4-Ethoxy-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol | HCID 59341027 | — |
Reaction Steps
Intermediate 47 was coupled with tyramine following procedure F. LC-MS showed the product had the expected M+H+ of 336. 1H NMR (Varian 300 MHz, DMSO-d6, shifts relative to the solvent peak at 2.49 ppm) δ 8.2 (d, 1H), 8.0 (d, 2H) 7.0 (m, 4H) 6.6 (d, 3H), δ 4.0 (q, 2H), 3.4 (t, 2H), δ 2.7 (t, 2H), 1.3 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-9eeb84db1c0b49d3a4777209fdcd9363 |
| Source note | uspto-grants-2012_09 |