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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2386427Generated: November 1, 2026

2-(AMINOETHYL)-1-N-BOC-PIPERIDINE → 2-{2-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/2386427

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(AMINOETHYL)-1-N-BOC-PIPERIDINEHCID 2756421—
Reactant3-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 24901965—
Product2-{2-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-ethyl}-piperidine-1-carboxylic acid tert-butyl esterHCID 86603276—

Reaction Steps

Intermediate 1 was coupled with 2-(2-Amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 431.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08268822B2
Source datasetuspto-grants-2012_09
ORD IDord-52d01ef6854749b9a55ef3728f35a721
Source noteuspto-grants-2012_09