Methanesulfonyl chloride → 2-(2-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	2-{2-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester	HCID 86603276	—
Product	2-(2-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester	HCID 86603277	—

Intermediate 57 was coupled with methanesulfonyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 509.