HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 3-({Acetyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 3-{[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86603279 | — |
| Product | 3-({Acetyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86603280 | — |
Reaction Steps
Intermediate 59 was coupled with acetyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 445.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-9676614eaedd4840895354b27159dc06 |
| Source note | uspto-grants-2012_09 |