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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2386434Generated: October 31, 2026

3-Acetylphenylboronic acid → 1-(3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-ethanone

https://huagongshe.com/reaction/2386434

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Acetylphenylboronic acidHCID 2734310—
Reactant4-[2-(4-Chloro-pyrimidin-2-ylamino)-ethyl]-phenolHCID 86603281—
Product1-(3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-ethanoneHCID 67044689—

Reaction Steps

Intermediate 61 was coupled with 3-acetyl phenylboronic acid following procedure A. LC-MS showed the product had the expected M+H+ of 334.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08268822B2
Source datasetuspto-grants-2012_09
ORD IDord-97c6f457b1524b6f8e19be16d467de8c
Source noteuspto-grants-2012_09