2-(3-Fluorophenyl)ethanamine → 4-(3-{2-[2-(3-Fluoro-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-3-(S)-methyl-piperazine-1-carboxylic acid tert-butyl ester

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Reaction Steps

Intermediate 68 was coupled with 3-fluorophenethylamine following procedure F. LC-MS showed the product had the expected M+H+ of 506. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) δ 8.4 (m, 2H) 8.0 (m, 1H) 7.7 (m, 1H) 7.5 (m, 2H) 7.0 (m, 4H) 5.3 (m, 1H) 3.9 (m, 4H) 3.7 (m, 4H) 3.0 (m, 4H) 1.6 (m, 3H) 1.4 (s, 9H).

Provenance & Evidence