L-Alaninol → 2-(S)-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-propan-1-ol

Participants

Reaction Steps

Intermediate 1 was coupled with 2-(S)-amino-propan-1-ol following procedure B. LC-MS showed the product had the expected M+H+ of 278. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) δ 8.4 (m, 1H) 7.8 (s, 1H) 7.7 (m, 1H) 7.5 (m, 1H) 7.3 (m, 1H) 7.0 (m, 1H) 3.8 (m, 1H) 3.6 (m, 1H) 3.4 (m, 1H) 3.1 (m, 1H) 2.6 (m, 1H) 0.9 (m, 3H).

Provenance & Evidence