HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Fluoro-4-methoxyphenyl)ethanamine → 4-(2-Aminoethyl)-2-fluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Fluoro-4-methoxyphenyl)ethanamine | HCID 426300 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 4-(2-Aminoethyl)-2-fluorophenol | HCID 193292 | — |
Reaction Steps
Intermediate 82 was dissolved in 200 mL of 48% aqueous HBr and the mixture heated to reflux for 2 hours. The Solvent was removed by rotary evaporation. The residue was taken up in 100 mL of ethanol and the solvent again removed. This was repeated twice more to remove residual water. LC-MS showed the product was >90% pure had the expected M+H+ of 156.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-4035c7512b6c4308a9a4a02c4ef4de14 |
| Source note | uspto-grants-2012_09 |