HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-Boc-piperidine → 4-[5-(2-Chloro-pyrimidin-4-yl)-2-methoxy-benzylamino]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Reactant | 5-(2-Chloro-pyrimidin-4-yl)-2-methoxy-benzaldehyde | HCID 53363596 | — |
| Product | 4-[5-(2-Chloro-pyrimidin-4-yl)-2-methoxy-benzylamino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86603291 | — |
Reaction Steps
Intermediate 86 was coupled with 4-Amino-piperidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product was >95% pure and had the expected M+H+ of 433.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-32558550b67b444d825c72cf1db04994 |
| Source note | uspto-grants-2012_09 |