HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Acetoxy-3-ethynyl-6-fluoro-naphthalen-2-yl)-acetic acid methyl ester → (4-Acetoxy-3-ethyl-6-fluoro-naphthalen-2-yl)acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Acetoxy-3-ethynyl-6-fluoro-naphthalen-2-yl)-acetic acid methyl ester | HCID 59326564 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (4-Acetoxy-3-ethyl-6-fluoro-naphthalen-2-yl)acetic acid methyl ester | HCID 59326550 | 98.7% |
Reaction Steps
To a solution of (4-acetoxy-3-ethynyl-6-fluoro-naphthalen-2-yl)-acetic acid methyl ester (50 mg) in methanol was added 10% palladium on carbon (10 mg). The resulting mixture was hydrogenated under 40 psi of hydrogen for 2 hours and filtered. The filtrate was concentrated in vacuo to afford (4-acetoxy-3-ethyl-6-fluoro-naphthalen-2-yl)acetic acid methyl ester (50 mg) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642629B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-96baf2beaa0b411dad6a853321e885c7 |
| Source note | uspto-grants-2014_02 |