HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde → 2-(2-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | 2-{2-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-ethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86603301 | — |
| Product | 2-(2-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86603300 | — |
Reaction Steps
Intermediate 106 was coupled with acetaldehyde following procedure E. LC-MS showed the product had the expected M+H+ of 445.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-6db73ffd696a4d99b06f2c3bdab5ebe8 |
| Source note | uspto-grants-2012_09 |