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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2386487Generated: October 31, 2026

2-(1H-Indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-2-(1H-indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/2386487

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(1H-Indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl esterHCID 22342889—
Reactant3-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 24901965—
Product4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-2-(1H-indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl esterHCID 86603303—

Reaction Steps

Intermediate 1 was coupled with 2-(1H-Indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 518.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08268822B2
Source datasetuspto-grants-2012_09
ORD IDord-c25ccac14c614d2da2d170db83cd36d3
Source noteuspto-grants-2012_09