HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1-Boc-3-methylpiperazine → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1-Boc-3-methylpiperazine | HCID 2756811 | — |
| Reactant | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Product | 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 86603305 | — |
Reaction Steps
Intermediate 1 was coupled with 3-(R)Methyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 403.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-8e175d24b8be4ca1be1979b3e4246822 |
| Source note | uspto-grants-2012_09 |