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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2386508Generated: October 31, 2026

tert-Butyl 2-phenylpiperazine-1-carboxylate → (2R)-tert-butyl 4-(3-(2-chloropyrimidin-4-yl)benzyl)-2-phenylpiperazine-1-carboxylate

https://huagongshe.com/reaction/2386508

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 2-phenylpiperazine-1-carboxylateHCID 16740572—
Reactant3-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 24901965—
Product(2R)-tert-butyl 4-(3-(2-chloropyrimidin-4-yl)benzyl)-2-phenylpiperazine-1-carboxylateHCID 86603309—

Reaction Steps

Intermediate 1 was coupled with 2-phenyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 465.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08268822B2
Source datasetuspto-grants-2012_09
ORD IDord-666fe9e9c93d4655be808c2610d5323f
Source noteuspto-grants-2012_09