HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde → 4(R)-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-3(S)-methyl-piperidine-1-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Reactant | benzyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate | HCID 67045008 | — |
| Product | 4(R)-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-3(S)-methyl-piperidine-1-carboxylic acid benzyl ester | HCID 86603319 | — |
Reaction Steps
Intermediate 1 was coupled with 4(R)-amino-3(S)-methyl-piperidine-1-carboxylic acid benzyl ester (prepared according to literature procedure (ref 1)) following procedure B. LC-MS showed the product had the expected M+H+ of 451.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-5c199afd29a14b888629e47f9ed9ca09 |
| Source note | uspto-grants-2012_09 |