HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde → 1-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-piperazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Reactant | 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester | HCID 86603321 | — |
| Product | 1-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-piperazine-2-carboxylic acid | HCID 86603320 | — |
Reaction Steps
Intermediate 1 was coupled with 4-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 433.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-aff4b5a6c02c4f158fdd14e22e2df3e8 |
| Source note | uspto-grants-2012_09 |