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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2386550Generated: October 31, 2026

1-Boc-3,3-dimethylpiperazine → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/2386550

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Boc-3,3-dimethylpiperazineHCID 22710387—
Reactant3-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 24901965—
Product4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl esterHCID 86603324—

Reaction Steps

Intermediate 1 was coupled with 3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 417.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08268822B2
Source datasetuspto-grants-2012_09
ORD IDord-5de4bf2689224632b74b4b3728df8d29
Source noteuspto-grants-2012_09