HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Boc-2,6-dimethylpiperazine → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Boc-2,6-dimethylpiperazine | HCID 22219926 | — |
| Reactant | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Product | 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 86603325 | — |
Reaction Steps
Intermediate 1 was coupled with 2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 417.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-94b397e7437f44b9a262653fe4bc0e2a |
| Source note | uspto-grants-2012_09 |