HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloropyrimidine → 5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | (4-Fluoro-3-formylphenyl)boronic acid | HCID 2778651 | — |
| Product | 5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde | HCID 24901981 | 40% |
Reaction Steps
2,4 dichloropyrimidine and 4-fluoro-3-formylphenylboronic acid was coupled following procedure A. The yield was 40%. LC-MS showed the product was >95% pure and had the expected M+H+ of 237.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268822B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-39a9c358790c41cb975e2d0dd4369817 |
| Source note | uspto-grants-2012_09 |