HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (4-Chloro-phenyl)-(2-hydrazino-9-methyl-9H-purin-6-yl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-Chloro-N-(4-chlorophenyl)-9-methyl-9H-purin-6-amine | HCID 59293637 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (4-Chloro-phenyl)-(2-hydrazino-9-methyl-9H-purin-6-yl)amine | HCID 59293633 | 90.1% |
Reaction Steps
(2-Chloro-9-methyl-9H-purin-6-yl)-(4-chloro-phenyl)amine (3.58 g, 12.1 mmol) was dissolved in tetrahydrofuran (50 mL). Hydrazine monohydrate (26 mL, 536 mmol) was added and the reaction mixture was heated to reflux over night. The next day water was added and the resulting solid was collected by filtration, washed with water and dried to give (4-chloro-phenyl)-(2-hydrazino-9-methyl-9H-purin-6-yl)-amine (3.16 g, 90%) as a white crystalline compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268838B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-1a7a7881f5114edba5a7ea7f99f57714 |
| Source note | uspto-grants-2012_09 |