Water → NS13001

HRID 2386597Notes

Reaction equation

HRID 2386597 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:17]=[C:16]([NH:18][NH2:19])[N:15]=[C:14]3[C:10]=2[N:11]=[CH:12][N:13]3[CH3:20])=[CH:4][CH:3]=1.[CH3:21][C:22](=O)[CH2:23][C:24](=O)[CH3:25].O>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:17]=[C:16]([N:18]3[C:24]([CH3:25])=[CH:23][C:22]([CH3:21])=[N:19]3)[N:15]=[C:14]3[C:10]=2[N:11]=[CH:12][N:13]3[CH3:20])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 31261AcetylacetoneHCID 59293633(4-Chloro-phenyl)-(2-hydrazino-9-methyl-9H-purin-6-yl)amine

Product 1

HCID 44472568NS13001Yield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(4-Chloro-phenyl)-(2-hydrazino-9-methyl-9H-purin-6-yl)amine (4.15 g, 14.3 mmol) and 2,4-pentanedione (2.0 mL, 19.1 mmol) in ethanol (100 mL) were heated to reflux for 20 min. Water was added and the white crystalline compound was collected by filtration, washed with water and dried to give (4-chloro-phenyl)-[2-(3,5-dimethyl-pyrazol-1-yl)-9-methyl-9H-purin-6-yl]-amine (4.25 g, 84%).

Workup

  1. temperatureto reflux for 20 min
  2. filtrationthe white crystalline compound was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-9d9a6416f6724a9d91215cb5ed58a7a1
Source dataset
uspto-grants-2012_09
Patent number
US08268838B2

Reaction notes

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