Hydrochloric Acid → HCID 59299595, compound

Participants

Reaction Steps

A stirred solution of methyl 1,3-dibutyl-2,6-dioxo-7-(2-propen-1-yl)-2,3,6,7-tetrahydro-1H-purine-8-carboxylate (1.30 g, 3.6 mmol) in MeOH (15 ml) was treated with LiOH (215 mg) and water (1.5 ml). After 3 hours at rt the mixture was diluted with water and the pH adjusted to ca. pH5 with 2M HCl(aq). EtOAc was added and then separated, washed with brine, dried (MgSO4) and concentrated to afford the title compound as a yellow solid 85% pure (1.2 g, 88%). m/z. 349.2 [MH+].

Provenance & Evidence