N-bromobutanimide → HCID 57929479, compound

Participants

Reaction Steps

To a mixture of 5-amino-8-cyclobutyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (1.3 g, 4.46 mmol) in DCM (120 mL) at 0° C. was added N-bromosuccinimide (0.87 g, 4.9 mmol) in 5 portions over 5 min. After stirring for 30 min, the DCM was evaporated under reduced pressure and the residue treated with 100 mL water and 100 mL NaHCO3 (sat'd, aq). The crude product was extracted into EtOAc (2×100 mL). The combined organic layers were washed with NaHCO3 (4×60 mL) and water (2×50 mL) and evaporated under reduced pressure to give 1.3 g of 5-amino-6-bromo-8-cyclobutyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one as a brown solid.

Provenance & Evidence