HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-1-(bromomethyl)-2-chlorobenzene → HCID 67546105, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-1-(bromomethyl)-2-chlorobenzene | HCID 21914486 | — |
| Reactant | 2,3-Dihydro-1-methyl-2-oxo-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylic acid | HCID 67546116 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 67546105 | HCID 67546105 | — |
Reaction Steps
In analogy to Example 49, step 1, 1-methyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylic acid was converted to the acid chloride and subsequently reacted with 4-bromo-1-bromomethyl-2-chloro-benzene in the presence of zinc and tetrakis(triphenylphosphine)palladium(0) to give the title compound as a light yellow solid. MS (m/e, ISP neg. ion)=392.9 [M−H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268820B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-e1fb17807dc540c19e72b9f8b9c2b9c7 |
| Source note | uspto-grants-2012_09 |