HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid | HCID 11264608 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylate | HCID 71299630 | — |
Reaction Steps
Oxalyl chloride (0.5 ml) was added to a solution of 2-chloro-5-(trifluoromethyl)isonicotinic acid (CAS Reg. No. 505084-58-2, 68 mg) in DCM (5 ml). DMF (1 drop) was added and the resulting mixture was stirred overnight at room temperature. Methanol (5 ml) was added and the mixture was concentrated to dryness. The crude product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268820B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-392ec75cd9614ab18dd961e4217e665d |
| Source note | uspto-grants-2012_09 |