HRID2386837

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)Oc1cc(C(F)(F)F)c2cc(C(=O)O)ccc2n1

HCID66697096

未命名化合物

HCID66697120

未命名化合物

HCID86645879

未命名化合物

PRODUCTS

生成物

结构：CC(C)Oc1cc(C(F)(F)F)c2cc(C(=O)Cc3ccc(Oc4ccc(C#N)c(Cl)c4)cc3Cl)ccc2n1

HCID66697118

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23994

Zinc

PROCEDURE

实验过程

In analogy to Example 49, step 1, 2-isopropoxy-4-trifluoromethyl-quinoline-6-carboxylic acid was converted to the acid chloride and subsequently reacted with 4-(4-bromomethyl-3-chloro-phenoxy)-2-chloro-benzonitrile in the presence of zinc and tetrakis(triphenyl-phosphine)palladium(0) to give the title compound as a yellow oil. MS (m/e, ISP neg. ion)=557.0 [M−H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5d535dea7b784f30b2c47d8405044edb
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08268820B2
来源说明: uspto-grants-2012_09

反应 SMILES

[CH:1]([O:4][C:5]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:19](O)=[O:20])[CH:11]=2)[N:6]=1)([CH3:3])[CH3:2].CN1C2C=CC(C(Cl)=O)=CC=2OC1=O.Br[CH2:37][C:38]1[CH:53]=[CH:52][C:41]([O:42][C:43]2[CH:50]=[CH:49][C:46]([C:47]#[N:48])=[C:45]([Cl:51])[CH:44]=2)=[CH:40][C:39]=1[Cl:54]>[Zn]>[Cl:51][C:45]1[CH:44]=[C:43]([O:42][C:41]2[CH:52]=[CH:53][C:38]([CH2:37][C:19]([C:10]3[CH:11]=[C:12]4[C:7](=[CH:8][CH:9]=3)[N:6]=[C:5]([O:4][CH:1]([CH3:2])[CH3:3])[CH:14]=[C:13]4[C:15]([F:16])([F:17])[F:18])=[O:20])=[C:39]([Cl:54])[CH:40]=2)[CH:50]=[CH:49][C:46]=1[C:47]#[N:48]