HRID2386839

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67803

Tetramethylammonium fluoride

C4H12FN

HCID552549

(Trifluoromethyl)trimethylsilane

C4H9F3Si

结构：CC(C)Oc1cc(C(F)(F)F)c2cc(C(=O)C(C)c3ccc(Oc4ccc(C#N)c(Cl)c4)cc3Cl)ccc2n1

HCID66697136

未命名化合物

PRODUCTS

生成物

结构：CC(C)Oc1cc(C(F)(F)F)c2cc(C(O)(C(C)c3ccc(Oc4ccc(C#N)c(Cl)c4)cc3Cl)C(F)(F)F)ccc2n1

HCID86645881

未命名化合物

PROCEDURE

实验过程

In analogy to Example 1, step 3, 2-chloro-4-{3-chloro-4-[2-(2-isopropoxy-4-trifluoromethyl-quinolin-6-yl)-1-methyl-2-oxo-ethyl]-phenoxy}-benzonitrile was reacted with (trifluoromethyl)trimethylsilane and tetramethylammonium fluoride to give the title compound as an off-white gum. MS (m/e, ISP neg. ion)=641.1 [M−H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-422a3b455a454372ac304e10bb8fb158
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08268820B2
来源说明: uspto-grants-2012_09

反应 SMILES

[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]([CH3:38])[C:18]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]=[C:25]([O:30][CH:31]([CH3:33])[CH3:32])[CH:24]=[C:23]4[C:34]([F:37])([F:36])[F:35])=[O:19])=[C:13]([Cl:39])[CH:12]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:40][C:41]([Si](C)(C)C)([F:43])[F:42].[F-].C[N+](C)(C)C>>[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]([CH3:38])[C:18]([OH:19])([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]=[C:25]([O:30][CH:31]([CH3:33])[CH3:32])[CH:24]=[C:23]4[C:34]([F:35])([F:37])[F:36])[C:41]([F:43])([F:42])[F:40])=[C:13]([Cl:39])[CH:12]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]