3-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → HCID 72310148, compound

HRID 2386879Notes

Reaction equation

HRID 2386879 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:26])[C:9]([C:15]2[CH:16]=[CH:17][C:18]3[O:22][C:21](=[O:23])[N:20]([CH3:24])[C:19]=3[CH:25]=2)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[F:31][C:32]1[CH:33]=[C:34](B(O)O)[CH:35]=[CH:36][C:37]=1[C:38]([O:40][CH3:41])=[O:39]>>[CH3:41][O:40][C:38]([C:37]1[CH:36]=[CH:35][C:34]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([CH3:26])[C:9]([OH:14])([C:15]3[CH:16]=[CH:17][C:18]4[O:22][C:21](=[O:23])[N:20]([CH3:24])[C:19]=4[CH:25]=3)[C:10]([F:12])([F:13])[F:11])=[C:4]([C:27]([F:29])([F:30])[F:28])[CH:3]=2)=[CH:33][C:32]=1[F:31])=[O:39]

Participants

3

Reactant 2

HCID 27828183-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 72310129HCID 72310129, compound

Product 1

HCID 72310148HCID 72310148, compound

Procedure

The title compound was prepared in analogy to Example 117 from 5-[2-(4-bromo-2-trifluoromethyl-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3-methyl-3H-benzooxazol-2-one (obtained in Example 193, step 3) by Suzuki coupling with 3-fluoro-4-methoxycarbonyl-benzeneboronic acid [CAS Reg. No. 505083-04-5]. MS (m/e)=572.1 [M+H+].

Sources & evidence

ORD record
ord-9b3568c9fed74526871a9cbb86d9c5f4
Source dataset
uspto-grants-2012_09
Patent number
US08268820B2

Reaction notes

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