Prolinol, (R)- → HCID 57457556, compound

Participants

Reaction Steps

(2S)-2-methylpyrrolidine hydrobromide (2.70 g, 16.3 mmol), 3-bromopropanol (2.49 g, 17.9 mmol) and potassium carbonate (6.75 g, 48.9 mmol) were mixed in tetrahydrofuran (20 mL), and stirred at 60° C. for 18 hours. The precipitate was filtered off, and the filtrate was concentrated. The residue was distilled under reduced pressure, and the target compound (1.88 g, 80%) was thus obtained as a colorless oily substance. (2S)-2-methyl-pyrrolidine hydrobromide was manufactured by the method described in the literature (J. Org. Chem., 1989, Vol. 54, p. 209) using D-prolinol as starting material.

Provenance & Evidence