Methanol → HCID 86600242, compound

Participants

Reaction Steps

4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}aniline was obtained as a light brown oily substance by the method according to Example 138, using (2R)-2-methylpyrrolidine hydrobromide, 3-bromopropanol and 4-nitrophenol as starting materials. The obtained oily substance was dissolved in ethyl acetate, 1 Eq of a methanol solution of p-toluenesulfonic acid monohydrate was added, and the target compound was obtained as a colorless solid by filtering off the solid produced. (2R)-2-methylpyrrolidine hydrobromide was manufactured by the method described in the literature (J. Org. Chem., 1989, Vol. 54, p. 209).

Provenance & Evidence