HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Bromopropyl)pyrrolidine hydrobromide → 6-methoxy-2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]pyrido[3,4-d]-pyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Bromopropyl)pyrrolidine hydrobromide | HCID 20135920 | — |
| Reactant | 3-(4-hydroxyphenyl)-6-methoxy-2-methylpyrido[3,4-d]pyrimidin-4(3H)-one | HCID 23151204 | — |
| Product | 6-methoxy-2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]pyrido[3,4-d]-pyrimidin-4(3H)-one | HCID 23151361 | — |
Reaction Steps
The title compound was synthesized as a white solid (m.p.: 123-126° C.) by the method according to Example 63, using 3-(4-hydroxyphenyl)-6-methoxy-2-methylpyrido[3,4-d]pyrimidin-4(3H)-one synthesized in Example 197 and 1-(3-bromopropyl)pyrrolidine hydrobromide as starting materials, followed by recrystallization (ethyl acetate/diethyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268842B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-7c8bda9eb137470e96e01dd8d97d6a24 |
| Source note | uspto-grants-2012_09 |